I think there absolutely is. I haven't actually met a single coworker at my current job of over 3 years, since the nearest office is almost 500 miles from me, and it absolutely feels less "real" because of it. I do my job well enough, but it and my employer feel more like an abstract concept than anything else. I'm not one to care too much about a specific job in the first place, but I feel much less connected and engaged, and the job feels even less important to my life than when I was working retail/restaurants, even though I know that's objectively untrue. It doesn't help that I'm on a very small team and only really talk to a handful of people a few times a week.